Multiscale approaches to investigate the conformational landscape of flexible protein assemblies: Deciphering the NADPH oxidase complex

PI:  Sophie Sacquin-Mora, co-PI: Antoine Taly

Laboratory of Theoretical Biochemistry

2-year contract

The NAPDH oxidase (NOX) complex is an important source of reactive oxygen species in the cell, and its regulation plays an important role in pathogen killing processes. NOX comprises several folded domains separated by flexible disordered linkers. The goal of the project is to develop a multiscale approach, using all-atom and coarse-grain representations, to investigate NOX dynamic properties. This model will help identify key residues that could be targeted when trying to modulate the complex activity.

Berlow et al (2015) FEBS Lett 589(19):2433
Dupre-Crochet al (2013) J Leuk Biol 94(4):657 
Nunes et al (2013) Traffic 14(11):1118
Ziegler et al (2019) J Biol Chem 294(11):3824
Sumimoto H (2008) FEBS J 275(13):3249
Laurin et al (2017) Biochemistry 56(12):1746
Sacquin-Mora (2018) J Struc Biol 203(3):195 
Magnani et al (2017) PNAS 114(26):6764
 

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