Post-doc Structural biology of RNA-protein complexes

PI : Carine Tisné

Postdoc length: 2 years

Work place: Microbial Gene Expression Laboratory

Contact: Carine Tisné (

A postdoctoral position is available in the group “RNA biogenesis, architecture and interactions” led by Carine Tisné in the Institute of Physico-chemical Biology (IBPC) in Paris, to work on RNA-mediated gene expression regulation. RNAs are heavily co- or post-transcriptionally modified, with the largest diversity of modifications found in tRNAs. Given the widespread presence of post-transcriptional RNA modifications in all classes of RNAs and in all domains of life and their dynamics, it is clear that RNA functions must have evolved under the influence of RNA modifications. We want to elucidate how RNA maturation control or influence RNA functions. A multi-disciplinary approach involving biochemical, biophysical and cellular experiments will be used to address these questions of RNA biology. The ultimate goal of the project is to advance our understanding of RNA-based regulation, by means of biochemical reconstitution and structural characterisation using purified protein/RNA components. Candidates will hold or about to be awarded a PhD in Biochemistry, Biophysics or Molecular Biology and must have a proven track record of research achievements. Previous experience in the analysis of multi-protein complexes and protein-RNA interactions, as well as familiarity with biophysical techniques such as X-ray crystallography, electron microscopy and single-particle analysis would be an advantage. This position may lead to a submission to the CNRS national competition for a permanent position.