Regulation of Mitochondrial function/dysfunction by Focused Ultrasound

PI:  Phuong Nguyen

Laboratory of Theoretical Biochemistry

2-year contract

Ion channels are key regulators of mitochondrial functions. The transport of ions across the mitochondrial membrane is essential in maintaining energy production for the cell. The core aim of this project is in the development of novel nonequilibrium simulation methods to unravel the underlying molecular mechanism of how focused ultrasound influences ion channels activity and leads to regulation of mitochondrial function/dysfunction. Simulated ionic currents will offer an unprecedented view on the ion permeation process, protein conformational changes and lipid rearrangements with the timescale extending from picoseconds to microseconds.

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V. H. Man, P. Derreumaux, P. H. Nguyen. Nonequilibrium all-atom molecular dynamics simulation of the ultrasound induced bubble vibration and application to dissociate amyloid fibrils. J. Chem. Phys. 2016, 145, 174113

V. H. Man, P. M. Truong, M. S. Li, J. Wang, V. O. Nguyen-Thi, P. Derreumaux and P.H. Nguyen. Molecular mechanism of the cell membrane pore formation induced by bubble stable cavitation. J. Phys. Chem. B. 2019, 123, 71.

V. H. Man, M.S. Li, J. Wang, P. Derreumaux and P.H. Nguyen. Interaction mechanism between the focused ultrasound and lipid membrane at the molecular level. J. Chem. Phys. 2019, 150, 215101.

V. H. Man, M.S. Li, J. Wang, P. Derreumaux, T. T. Nguyen, S. Nangia and P.H. Nguyen. Molecular mechanism of ultrasound interaction with a blood brain barrier model. Chem. Phys. 2020, 153, 045104.

V. H. Man, M.S. Li, J. Wang, P. Derreumaux and P.H. Nguyen. Molecular Mechanism of Ultrasound Induced  Structural Defects in Liposomes: a Nonequilibrium Molecular Dynamics Simulation Study. Langmuir 2021, 37, 7945

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