Regulation of Mitochondrial function/dysfunction by Focused Ultrasound
Ion channels are key regulators of mitochondrial functions. The transport of ions across the mitochondrial membrane is essential in maintaining energy production for the cell. The core aim of this project is in the development of novel nonequilibrium simulation methods to unravel the underlying molecular mechanism of how focused ultrasound influences ion channels activity and leads to regulation of mitochondrial function/dysfunction. Simulated ionic currents will offer an unprecedented view on the ion permeation process, protein conformational changes and lipid rearrangements with the timescale extending from picoseconds to microseconds.
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V. H. Man, P. M. Truong, M. S. Li, J. Wang, V. O. Nguyen-Thi, P. Derreumaux and P.H. Nguyen. Molecular mechanism of the cell membrane pore formation induced by bubble stable cavitation. J. Phys. Chem. B. 2019, 123, 71.
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V. H. Man, M.S. Li, J. Wang, P. Derreumaux and P.H. Nguyen. Molecular Mechanism of Ultrasound Induced Structural Defects in Liposomes: a Nonequilibrium Molecular Dynamics Simulation Study. Langmuir 2021, 37, 7945
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